devprof <--- not sure why you have this option enabled as you're not likely to have a developer profile?
exchandler <--- this one you should probably enable, it's very useful (it'll probably make a popup say there was an exception caught, if that's the case... you should probably look into the game data of the games which causes it)
** edit: **
Based on your settings above, i'd guess your problem is related to a Fatal Game Crash, which are often caused by corrupt/missing data, this can also be caused by your memory beeing bad for instance, try other memories and/or slow format it to see if it works better